Abstract: Establishing a credible, traceable, and internationally recognized life cycle assessment (LCA) database for leather chemicals is crucial for accurately assessing the potential environmental impacts of China's leather products. This study systematically analyzed domestic and international LCA case studies of leather chemicals and assessed the current status of related databases. Based on this analysis, we developed a plan for constructing a domestic LCA database for leather chemicals and proposed a suitable LCA framework. The research revealed a lack of comprehensive LCA databases for leather chemicals. This limits the accurate assessment of the environmental footprint of leather, including its carbon footprint. We recommend a three-tiered approach for database construction, based on the usage and environmental impacts of leather chemicals: Level I (tanning agents, fatliquors, and finishing agents), Level II (surfactants, enzyme preparations, and dyes), and Level III (soaking auxiliaries and other leather-specific auxiliaries). Guided by ISO 14040 and ISO 14044, the study scope of leather chemicals should be defined within a "cradle-to-gate" system boundary, encompassing production, packaging, and transportation of leather chemicals. This study provides systematic guidance for constructing an LCA database for leather chemicals, supporting the establishment of a carbon footprint management system in the leather industry.