Abstract: With the increasing personalized demand in the garment consumption market, leather garment design is becoming increasingly diversified. Based on the excellent plasticity of leather fabrics and the advantages of natural materials, a series of practical explorations were carried out by exploring the three-dimensional space of garment and combining the leather sculpture technology. According to the experimental results, it is found that in the sculpture molding, sculpture resin is suitable for the small area, small volume, and less detailed forms, while the water-based sculpture clay is suitable for the large area and large volume shaping. In terms of leather material selection, the thick vegetable-tanned goatskin is suitable for the large area of simple and stiff styling; the slightly thinner vegetable-tanned goatskin is easier to shape the curve of large curvature; the soft and thin sheepskin has obvious advantages in completing complex structures. After the shaping treatment, the resulting leather can meet the requirements for clothing space shaping, and its excellent performance and texture are greatly beneficial for the three-dimensional expression of leather sculpture garment.