Abstract: Leather goods, such as leather clothing and leather shoes, have become the daily necessities of people, but the poor antibacterial property of their surfaces is easy to cause the reproduction of bacteria and fungi, which not only affects their quality but also brings a threat to the health of consumers. In this work, a "sandwich" type of organic/inorganic composite antibacterial coating was stably constructed by layer-by-layer assembly of positively charged polyethylene glycol-graft-chitosan polymer and negatively charged gallic acid modified silver nanoparticles on the leather surface. The unique sandwich structure of the composite coating showed high antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans. After 30 times of washing, the antibacterial efficiency of the coating still reached more than 90%, indicating its excellent washable resistance and stability. The results show that the "sandwich" organic/inorganic composite antibacterial coating is expected to be an ideal antibacterial coating for leather surface.