Abstract: This article research on the antibacterial durability of PVC artificial leather, microfiber leather and genuine leather, under natural aging and Xenon-Arc aging test conditions respectively. The results show that in the natural aging test, PVC and microfiber leather reflected a significant antibacterial efficiency decay; while the genuine leather remain excellent antibacterial efficiency with wrinkle and hardening phenomenon; and that the Xenon-Arc aging test does not seem to impact the antibacterial performance.